ONE-CARBON METABOLISM GENE POLYMORPHISM CORRELATE WITH LEVELS OF DNA METHYLTRANSFERASES IN PATIENTS WITH MIGRAINE

Migraine is a common, disabling disorder characterized by attacks of 4 to 72 h severe headache and associated autonomic neurological symptoms. In the present study we analyzed expression DNMT1, DNMT3a, DNMT3b in patients with migraine compared healthy controls as well association between levels DNMTs LINE-1 methylation status MTHFR C677T variant. Materials Method: A total 48 individuals were enrolled this (24 24 age-matched controls). The protocol was approved Ethics Committee Tbilisi State Medical University. Results: We observed that correlated of DNMT3a migraine. In addition, DNMT3a TT genotypes gene rs1801133 polymorphism significantly lower CC genotypes. Conclusions: Differential may play an important role pathogenesis Further investigation enzymes involved DNA larger number samples provide insight into development novel treatments for episodic and/or chronic